Irresistible BEST Mac and Cheese Meatloaf Casserole Recipe

As the aroma of baking meatloaf fills the kitchen, I find myself transported back to family dinners of my childhood, where comfort food was a hug served on a plate. Today, I’m thrilled to share my take on a cherished classic—the BEST Mac and Cheese Meatloaf Casserole. This delightful dish is a scrumptious combination of two beloved favorites, bringing together the savory heartiness of meatloaf and the creamy indulgence of mac and cheese.

Whether you’re craving something warm and satisfying after a long day or looking for the perfect meal to impress your loved ones, this casserole is your answer. Picture a golden-brown top of cheesy goodness enveloping a tender meatloaf, with a sweet barbecue glaze that adds the perfect touch of flavor. Best of all, it’s incredibly easy to customize! Want a veggie-packed option? Or maybe a spicy twist? I’ve got you covered. Let’s dive into this comforting recipe that’s sure to become a staple on your dinner table.

Why is this the BEST Mac and Cheese Meatloaf Casserole?

Comfort Food Revolution: Combining two beloved dishes into one harmonious casserole creates an irresistible meal that’s perfect for any occasion.

Endless Customization: Easily tweak this recipe with veggie-packed or spicy twists to satisfy every palate.

Family-Friendly Appeal: It’s a dish that both kids and adults will adore, making it ideal for busy weeknights or family gatherings.

Time-Saving Delight: Quick to prepare with minimal cleanup, it’s perfect for those on-the-go days.

Memorable Flavor Experience: Each bite delivers rich, savory goodness, topped off with a sweet barbecue glaze that enhances the dish.

This BEST Mac and Cheese Meatloaf Casserole is nostalgia at its finest—serving up all the cozy vibes while bringing everyone to the table!

BEST Mac and Cheese Meatloaf Casserole Ingredients

For the Meatloaf
Ground Beef – Provides a hearty base with rich flavor and protein; substitute ground turkey for a leaner option.
Breadcrumbs – Binds the mixture and adds texture; panko can substitute for a lighter result, or use homemade breadcrumbs.
Egg – Acts as a crucial binder to keep the meatloaf intact when sliced.
Milk – Ensures moisture in the meatloaf; any fat percentage will do.
Onion – Adds aromatic flavor; finely chop for even distribution.
Garlic Powder – Enhances savoriness without texture; evenly distributes throughout the mixture.
Barbecue Sauce – Creates a sweet and tangy glaze during baking; use ketchup mixed with brown sugar and vinegar as an alternative.

For the Mac and Cheese
Elbow Macaroni – The classic pasta choice that holds onto the cheese sauce well; short pasta can be substituted.
Butter – Creates the roux necessary for the cheese sauce base.
Flour – Works with butter to thicken the cheese sauce, providing that creamy texture.
Cheddar Cheese – Offers a sharp, rich flavor; medium or sharp varieties work best. Mix with Monterey Jack or Gruyère for a different taste.
Paprika – Optional for added warmth and a beautiful color in the cheese layer.
Milk – Whisked into the roux to create the béchamel sauce; ensures creaminess in the mac and cheese.

Don’t hesitate to explore the ultimate comfort of the BEST Mac and Cheese Meatloaf Casserole with your favorite variations!

How to Make the BEST Mac and Cheese Meatloaf Casserole

  1. Preheat Oven: Set your oven to 350°F (175°C), filling the kitchen with warmth and inviting aromas as it prepares for the magic to come.

  2. Prepare Meatloaf Mixture: In a large bowl, combine ground beef, breadcrumbs, egg, milk, chopped onion, garlic powder, and half of the barbecue sauce. Mix until everything is well incorporated; this will be the heart of your casserole!

  3. Form Meatloaf: Shape the mixture into a rectangular loaf, about 1.5 inches thick, and place it neatly in a baking dish. This is where the meatloaf starts to take form!

  4. Mix Mac and Cheese: Cook elbow macaroni until it’s al dente. In a saucepan, melt the butter and whisk in the flour to create a roux. Gradually add milk, whisking until you have a smooth béchamel. Stir in the cheddar cheese until melted, blending in paprika for a beautiful color. Toss the cooked macaroni in the cheese sauce until evenly coated.

  5. Assemble Casserole: Create a comforting layer by spreading the mac and cheese over the meatloaf, then drizzle the remaining barbecue sauce on top, enhancing the flavors and adding a sweet finish.

  6. Bake: Cover the casserole with foil and bake for 25 minutes. Remove the foil, letting it bake uncovered an additional 20 minutes, until the top is bubbly and golden—a feast for the eyes!

  7. Check for Doneness: Use a meat thermometer to ensure the meatloaf reaches an internal temperature of 160°F (71°C). A perfectly cooked meatloaf means a delicious meal for you and your loved ones!

Optional: Garnish with fresh parsley for a pop of color and a fresh taste.

Exact quantities are listed in the recipe card below.

BEST Mac and Cheese Meatloaf Casserole

BEST Mac and Cheese Meatloaf Casserole Variations

Feel free to put your spin on this comforting dish with these imaginative tweaks!

  • Veggie-Packed: Add finely diced bell peppers, carrots, or zucchini into the meat mixture for extra nutrition and flavor. The vibrant colors will entice everyone to dig in!

  • Spicy Twist: Incorporate diced jalapeños for a kick, and opt for pepper jack cheese in the mac and cheese layer. This variation will awaken your taste buds with a delightful heat!

  • Italian Style: Replace barbecue sauce with marinara, add Italian seasoning, and use mozzarella and parmesan cheeses. This Italian-inspired version will transport you to a cozy trattoria.

  • Gluten-Free: Substitute gluten-free breadcrumbs and pasta to make this dish suitable for those with dietary restrictions. Enjoy the same comforting flavors without the gluten!

  • Cheesy Addition: Mix in crumbled feta or goat cheese into the mac and cheese for an elevated, tangy flavor. It brings a new dimension to this already delightful dish.

  • Sweet & Savory: Drizzle a touch of maple syrup over the meatloaf before baking for a sweet contrast to the savory elements. This unexpected twist will surprise and delight!

  • Herbed Delight: Mix in fresh herbs like basil or thyme into the meat and cheese layers for an aromatic flavor boost. The fragrance of herbs adds a lovely freshness to your casserole.

  • Family-Friendly Sauce: Replace barbecue sauce with a homemade sauce using ketchup, brown sugar, and vinegar for a tangy sweetness. The kids will love this familiar flavor twist!

Expert Tips for the BEST Mac and Cheese Meatloaf Casserole

  • Thick Sauce Alert: Ensure your cheese sauce thickens adequately before layering; a runny sauce can make the casserole soggy and less enjoyable.

  • No Pink Meatloaf: Always check the meatloaf with a thermometer to reach 160°F (71°C) for safe and tasty results—no one wants an undercooked meal!

  • Fresh Cheese Counts: Use freshly grated cheese instead of pre-shredded. This simple swap prevents a grainy texture in your sauce, enhancing the dish’s creaminess.

  • Prep Ahead: Assemble the casserole up to 24 hours in advance and store it in the fridge. Add 10-15 minutes to baking time when cooking from cold for the BEST Mac and Cheese Meatloaf Casserole.

  • Vegetable Boost: Want to sneak in some veggies? Adding finely diced bell peppers or zucchini to the meat mixture not only adds nutrition but also vibrant color and flavor!

What to Serve with BEST Mac and Cheese Meatloaf Casserole?

Looking to elevate your meal alongside this comforting casserole? Here are some delightful pairings that will enhance your dining experience.

  • Simple Green Salad: Fresh, crisp greens tossed in a light vinaigrette balance the richness of the casserole. A touch of acidity can brighten the meal beautifully.

  • Roasted Veggies: Seasonal vegetables like carrots, zucchini, and bell peppers roasted to perfection add texture and flavor. Their slight sweetness complements the savory meatloaf beautifully.

  • Steamed Broccoli: Tender broccoli florets provide a nutritious crunch, helping to cut through the creamy cheese. Plus, the vibrant green is a feast for the eyes!

  • Garlic Bread: Crispy, buttery garlic bread adds a delightful crunch to the table. It’s perfect for soaking up any extra cheese sauce that oozes from the casserole.

  • Homemade Coleslaw: A crunchy coleslaw adds a refreshing element to contrast with the warmth of the casserole. Its tangy dressing invites pop and balance with each bite.

  • Sweet Potato Fries: Crispy sweet potato fries bring a hint of sweetness and soft texture, making them a fun and tasty companion.

  • Lemonade or Iced Tea: A refreshing drink like lemonade or iced tea brings brightness and quenching qualities, making the meal feel even more special.

  • Chocolate Chip Cookies: Finish off the meal with nostalgia by serving warm chocolate chip cookies. This classic dessert rounds off your comforting dinner with a sweet note!

How to Store and Freeze BEST Mac and Cheese Meatloaf Casserole

Fridge: Refrigerate leftovers in an airtight container for up to 3-4 days. This helps maintain freshness and flavors, allowing you to enjoy your delicious casserole later.

Freezer: For longer storage, freeze portions of the casserole in airtight containers for up to 3 months. When ready to eat, simply thaw overnight in the fridge.

Reheating: To reheat, microwave individual servings or place the whole casserole in a preheated oven at 350°F for 20-25 minutes until heated through. Enjoy the comforting flavors of your BEST Mac and Cheese Meatloaf Casserole once again!

Make Ahead Options

These BEST Mac and Cheese Meatloaf Casserole preparations are perfect for busy home cooks looking to save time during hectic weeknights! You can prepare the meatloaf mixture and mac and cheese sauce up to 24 hours in advance—just mix the ingredients together and store them separately in airtight containers in the refrigerator. To maintain optimal quality, be sure to cover the casserole with foil when assembling it and refrigerate until ready to bake. When you’re ready to serve, simply layer the mac and cheese over the meatloaf, drizzle with barbecue sauce, and bake. If baking from cold, expect to add an extra 10-15 minutes to the cooking time for a delicious meal ready to impress!

BEST Mac and Cheese Meatloaf Casserole

BEST Mac and Cheese Meatloaf Casserole Recipe FAQs

How do I choose the right ground beef for my meatloaf?
Absolutely! When selecting ground beef for your meatloaf, choose lean ground beef with a fat content of around 80/20 for the best flavor and moisture. If you prefer a leaner option, ground turkey is a great substitute that works well without compromising taste. Just be mindful that leaner meats can make the meatloaf a tad drier, so adding a bit more milk may help!

How should I store leftovers, and how long will they last?
Very! After enjoying your BEST Mac and Cheese Meatloaf Casserole, store any leftovers in an airtight container in the fridge for up to 3-4 days. Make sure to let the casserole cool completely before sealing it up to keep it fresh and ready for your next warm meal!

Can I freeze the casserole, and if so, how?
Certainly! To freeze your casserole, allow it to cool completely, then cut it into portions. Wrap each portion tightly in plastic wrap and then place them in airtight containers or freezer bags. It can be frozen for up to 3 months. When you’re ready to enjoy it again, simply thaw in the fridge overnight and reheat it in the oven at 350°F for about 20-25 minutes.

What should I do if my cheese sauce is grainy?
Don’t worry, it happens to the best of us! If your cheese sauce turns out grainy, it’s likely due to using pre-shredded cheese, which has anti-caking agents. To avoid this, always opt for freshly grated cheese. If you’re in a bind and have already made the sauce, try adding a splash of warm milk while whisking gently, which can help smooth it out.

Are there any dietary considerations I should be aware of?
Definitely! If you’re cooking for a family member or friend with dietary restrictions, you can easily make this dish gluten-free by substituting gluten-free breadcrumbs and pasta. Always keep in mind that certain cheeses may contain allergens; check the labels for any dairy-related concerns if anyone has lactose intolerance or allergies. Also, be cautious of the barbecue sauce you choose, as some contain gluten or other allergens.

Can I prepare the meatloaf mixture in advance?
Yes, you can! In fact, I often prepare the meatloaf mixture a day ahead to let the flavors meld together beautifully. Simply mix all the ingredients, shape the loaf, cover well with plastic wrap, and refrigerate. When you’re ready to bake, layer the mac and cheese as per the recipe instructions. Just remember to add about 10-15 extra minutes to the baking time if cooking straight from the fridge!

BEST Mac and Cheese Meatloaf Casserole

Irresistible BEST Mac and Cheese Meatloaf Casserole Recipe

Discover the BEST Mac and Cheese Meatloaf Casserole, a comforting blend of savory meatloaf and creamy mac and cheese, perfect for any occasion.
Prep Time 20 minutes
Cook Time 45 minutes
Total Time 1 hour 5 minutes
Servings: 6 slices
Course: Dinner
Cuisine: American
Calories: 500

Ingredients
  

For the Meatloaf
  • 1 lb Ground Beef Substitute ground turkey for a leaner option.
  • 1 cup Breadcrumbs Panko can substitute for a lighter result.
  • 1 large Egg Acts as a crucial binder.
  • 1/2 cup Milk Any fat percentage will do.
  • 1 medium Onion Finely chopped for even distribution.
  • 1 tsp Garlic Powder Enhances savoriness.
  • 1/2 cup Barbecue Sauce Use ketchup mixed with brown sugar as an alternative.
For the Mac and Cheese
  • 2 cups Elbow Macaroni Substitute short pasta if preferred.
  • 4 tbsp Butter Creates the roux for the cheese sauce.
  • 1/4 cup Flour Works with butter to thicken the cheese sauce.
  • 2 cups Cheddar Cheese Medium or sharp varieties work best.
  • 1 tsp Paprika Optional for added warmth.
  • 1/2 cup Milk Whisked into the roux for creaminess.

Equipment

  • Baking Dish
  • Large Bowl
  • saucepan
  • Whisk

Method
 

Preparation
  1. Preheat your oven to 350°F (175°C).
  2. In a large bowl, combine ground beef, breadcrumbs, egg, milk, chopped onion, garlic powder, and half of the barbecue sauce. Mix until well incorporated.
  3. Shape the mixture into a rectangular loaf, about 1.5 inches thick, and place it in a baking dish.
  4. Cook elbow macaroni until al dente. In a saucepan, melt the butter and whisk in flour to create a roux. Gradually add milk, whisking until smooth. Stir in cheddar cheese until melted. Toss macaroni in this cheese sauce.
  5. Spread the mac and cheese over the meatloaf and drizzle the remaining barbecue sauce on top.
  6. Cover with foil and bake for 25 minutes. Remove foil and bake uncovered for an additional 20 minutes until bubbly and golden.
  7. Use a meat thermometer to ensure the meatloaf reaches an internal temperature of 160°F (71°C).

Nutrition

Serving: 1sliceCalories: 500kcalCarbohydrates: 45gProtein: 30gFat: 25gSaturated Fat: 12gCholesterol: 90mgSodium: 850mgPotassium: 600mgFiber: 2gSugar: 4gVitamin A: 15IUVitamin C: 5mgCalcium: 20mgIron: 15mg

Notes

Optional: Garnish with fresh parsley for color and taste. Assemble up to 24 hours in advance, adding 10-15 minutes to baking time if refrigerated.

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